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CIRS
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Moisturizing
Moisturizing

Efficacy

Evaluation Model

Evaluation Indicator

Moisturizing

Keratinocytes

Expression of moisturization-related genes (AQP3, HAS3)

Keratinocytes

Expression of barrier-related genes (ZO-1, Claudin-1, Occludin)

HaCaT cell dehydration model

Cell vitality, cell morphology

3D skin model

Expression of moisturization- and barrier-related proteins

Next：Soothing

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